Biomaterials Research Laboratory
Starting in 2000 a biomaterials research laboratory had been set up at the Institute of Ion Beam Physics and Materials Research of the Forschungszentrum Rossendorf e.V. The topic of research was ion implantation to improve the biocompatibility of surfaces. The situation of the bio-laboratory in the physical institute offered a unique possibility for the interdisciplinary investigation of the biological response on physical surface properties. By means of ion implantation and various methods of film deposition it is possible to modify surface properties like hardness, roughness, crystalinity, electrical and electronic porperties, surface charges and chemical functional groups in a wide range. The biological research was on metabolism, differentiation, apoptotic and necrotic death of cells on foreign surfaces.
Unfortunately in October 2004 the laboratory had to be shut down completely due to priority shifts in the institute. All equipment got distributed to other institutes. Also none of the cell lines is available any more.
The current fields of research were:
Implants in contact with blood (leading topic)
- influence of the surface on proteins, especially of the clotting cascade
- influence of the surface on blood cells, especially with blood platelets
influence of the surface on blood vessel cells, especially with endothelial cells
Implants in contact with bone
- surface interaction with extracellular matrix proteins
- differentiation of mesenchymal stem cells on the surfaces
Informative Flyers and Posters are prepared which present the current fields of research. Below is a list of current and completed projects.